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Synthesis of 4-[4-(3-pyridinyl)imidazol-1-yl]-1-butylamine.
- Source :
- Journal of Chemical Research; 2011, Vol. 35 Issue 10, p600-601, 2p, 1 Diagram
- Publication Year :
- 2011
-
Abstract
- 4-[4-(3-pyridinyl)imidazol-1-yl]-1-butylamine, the side chain of telithromycin, is used for the synthesis of novel ketolide antibiotics. The key step in synthesising 4-[4-(3-pyridinyl)imidazol-1-yl]-1-butylamine involves the HBr-induced DMSO oxidation of 3-acetylpyridine to 3-pyridylglyoxal, which was not isolated but transformed directly into 4-(3-pyridyl)imidazole by a Debus reaction with ammonia and formaldehyde. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 35
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 74021180
- Full Text :
- https://doi.org/10.3184/174751911X13176543106368