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Rheumatic heart disease and risk of incident heart failure among community-dwelling older adults: A prospective cohort study.
- Source :
- Annals of Medicine; May2012, Vol. 44 Issue 3, p253-261, 9p, 4 Charts, 2 Graphs
- Publication Year :
- 2012
-
Abstract
- Background. Little is known about the association of rheumatic heart disease (RHD) with incident heart failure (HF) among older adults. Design. Cardiovascular Health Study, a prospective cohort study. Methods. Of the 4,751 community-dwelling adults ≥ 65 years, free of prevalent HF at baseline, 140 had RHD, defined as self-reported physician-diagnosed RHD along with echocardiographic evidence of left-sided valvular disease. Propensity scores for RHD, estimated for each of the 4,751 participants, were used to assemble a cohort of 720, in which 124 and 596 participants with and without RHD, respectively, were balanced on 62 baseline characteristics. Results. Incident HF developed in 33% and 22% of matched participants with and without RHD, respectively, during 13 years of follow-up (hazard ratio when RHD was compared to no-RHD 1.60; 95% confidence interval 1.13-2.28; P == 0.008). Pre-match unadjusted, multivariable-adjusted, and propensity-adjusted hazard ratios (95% confidence intervals) for RHD-associated incident heart failure were 2.04 (1.54-2.71; P < 0.001), 1.32 (1.02-1.70; P == 0.034), and 1.55 (1.14-2.11; P == 0.005), respectively. RHD was not associated with all-cause mortality (HR 1.09; 95% CI 0.82-1.45; P == 0.568). Conclusion. RHD is an independent risk factor for incident HF among community-dwelling older adults free of HF, but has no association with mortality. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07853890
- Volume :
- 44
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Annals of Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 73981924
- Full Text :
- https://doi.org/10.3109/07853890.2010.530685