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The caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges: results of a double-blinded, cluster-randomized clinical trial in an area of natural fluoridation.
- Source :
- International Journal of Paediatric Dentistry; May2012, Vol. 22 Issue 3, p180-190, 11p
- Publication Year :
- 2012
-
Abstract
- International Journal of Paediatric Dentistry 2012; 22: 180-190 Objective. Xylitol studies suggest caries reductions in the order of 50%. Based on animal/microbial studies, erythritol potentially has caries-preventive properties. However, clinical studies are required to confirm this.The aim of the study was to investigate the additional caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges delivered at school, relative to controls receiving comprehensive prevention, in a low-caries prevalence population. Methods. A 4-year, cluster-randomized, double-blinded clinical trial. Five hundred and seventy-nine 10-year-old consenting subjects from 21 schools were randomly assigned to one of five groups. Four groups used the lozenges on school days, in three teacher-supervised sessions daily, over 1 or 2 years. The daily amount was 4.7 g/4.6 g for xylitol/maltitol and 4.5 g/4.2 g for erythritol/maltitol. The groups received free examinations and care in the public health centre. Four hundred and ninety-six children were analysed. The main outcome measure was dentin caries increment based on a clinical examination at 4 years since the start. The groups were compared in relation to the increment using hierarchical logistic regression to adjust for potential clustering. Results. Use of xylitol/maltitol or erythritol/maltitol lozenges did not result in caries reduction. A strong relationship between baseline caries prevalence and the 4-year increment was observed (OR = 7.38; 95% CI: 3.78-14.41). Conclusions. The results suggest that in relatively low-caries conditions the school-based use of xylitol/maltitol or erythritol/maltitol lozenges would not have additional caries-preventive effect when compared with comprehensive prevention. [ABSTRACT FROM AUTHOR]
- Subjects :
- DIAGNOSIS of dental caries
CAVITY prevention
XYLITOL
ALCOHOLS (Chemical class)
CARBOHYDRATES
CHI-squared test
CONFIDENCE intervals
EPIDEMIOLOGY
PHYSICAL diagnosis
QUESTIONNAIRES
RESEARCH funding
STATISTICS
LOGISTIC regression analysis
SAMPLE size (Statistics)
DATA analysis
RANDOMIZED controlled trials
BLIND experiment
DATA analysis software
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 09607439
- Volume :
- 22
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- International Journal of Paediatric Dentistry
- Publication Type :
- Academic Journal
- Accession number :
- 73931034
- Full Text :
- https://doi.org/10.1111/j.1365-263X.2011.01182.x