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Factors associated with viral load suppression in HIV-infected pregnant women in Rio de Janeiro, Brazil.
- Source :
- International Journal of STD & AIDS; Jan2012, Vol. 23 Issue 1, p44-47, 4p, 2 Charts
- Publication Year :
- 2012
-
Abstract
- Viral load (VL) near delivery is a determinant of mother-to-child transmission (MTCT) of HIV. To evaluate factors associated with an undetectable VL near delivery in HIV-infected pregnant women receiving highly active antiretroviral therapy (HAART) and non-HAART regimens, HIV-infected pregnant women with a detectable VL at entry and having used antiretrovirals for ≤4 weeks before delivery were selected. Multivariate analysis was employed using binary logistic unconditional models; the dependent variable was having a VL <400 copies/mL near delivery. VL suppression was achieved in 403/707 women (57%): 65.4% in the HAART group, but only 26% in the non-HAART group P = 0.001. Duration of HAART was correlated with VL suppression, with maximum benefit seen after ≤12 weeks of therapy (odds ratio [OR]: 2.51; 95% confidence interval [CI]: 1.72-3.65). CD4+ cell count near delivery (OR: 1.53; 95% CI: 1.06-2.20) and baseline VL (OR: 0.74; 95% CI: 0.58-0.94) were also independently associated with VL suppression. Overall MTCT rate was 1.6%. HAART for ≤12 weeks, baseline VL and CD4 cell count near delivery were independently associated with viral suppression near delivery. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09564624
- Volume :
- 23
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- International Journal of STD & AIDS
- Publication Type :
- Academic Journal
- Accession number :
- 73802640
- Full Text :
- https://doi.org/10.1258/ijsa.2011.010545