Influences of different adenosine receptor subtypes on catalepsy in mice.

The effects of adenosine A and A receptors on catalepsy were studied in mice. The adenosine agonists 5-N′-ethylcarboxamide-adenosine (NECA), N-phenylisopropyladenosine (PIA) and N-cyclohexyladenosine (CHA) induced dose dependent catalepsy. The A adenosine antagonist 8-phenyltheophylline (8-PT) potentiated catalepsy induced by NECA, R-PIA and CHA. However, theophylline did not potentiate but inhibited the responses induced by NECA, R-PIA and CHA. Neither 8-PT nor theophylline alone has any effect on catalepsy in mice. It is concluded that catalepsy induced by the adenosine agonists may be due to A receptor stimulation and that the A antagonism may potentiate the response. [ABSTRACT FROM AUTHOR]