Profil de la T.R.H. en psychopharmacologie expérimentale.

The following behavioral modifications were observed after a single i.p. administration of T.R.H. (thyreo-tropin-releasing hormone) in mice or rats at doses higher than 4mg · kg: I. an increased reactivity to stimuli, II. periods of excitation alternating with periods of aggressivity, III. unusual movements ('tail-rattling' and 'wet-dog'), IV. the reserpine- or oxotremorine-induced hypothermia was antagonized in mice by T.R.H. in doses of 1 mg · kg and higher, but only a few other symptoms were influenced. The prochlorperazine-induced catalepsy in rats was antagonized by T.R.H.; under the experimental conditions, sudden hyperkinetic episodes were observed. The toxicity of pargyline- l-Dopa association was slightly increased, amphetamine- or apomorphine-induced stereotyped behavior was unchanged. This spectrum of activity is different from other known psychotropic drugs. [ABSTRACT FROM AUTHOR]