Cycloleucine (1-amino-cyclopentane carboxylic acid): Tubular reabsorption and inhibitory effect on amino acid transport in the rat kidney (microperfusion experiments).

Renal tubular reabsorption of cycloleucine (1-amino-cyclopentane carboxylic acid) was studied in vivo et situ by continuous microperfusion of single proximal tubules of the rat. The results show: A maximal possible permeability coefficient for cycloleucine (<6·10 cm·sec) was calculated. Assuming simple 2-parameter kinetics, V and K for tubular reabsorption of cycloleucine were estimated. It can be concluded from the present results that cycloleucine is reabsorbed by a mechanism that transports l-phenylalanine, but not by the system shared by dibasic amino acids. [ABSTRACT FROM AUTHOR]