Post-ischemic reactive hyperemia of the isolated perfused brain of the dog.

In 13 experiments the brains of dogs were perfused through an extracorporeal circuit connecting the donor's femoral artery to the internal maxillary artery of the isolated head, whose extracerebral vessels were ligated. Complete ischemias of 1, 5, 10, 20 and 30 min were performed. Cerebral blood flow was measured as total outflow from the confluence of sinuses. Perfusion pressure in the circle of Willis was recorded via a cannula in the basilar artery. Cerebral oxygen-consumption, ECoG and temperature of the brain as well as arterial pO, pCO and pH were controlled. Only those experiments are included in this study, in which these parameters were normal. The pressure-flow relationship of the cerebral vasculature tested prior to each complete ischemia showed autoregulatory behavior. [ABSTRACT FROM AUTHOR]