Back to Search
Start Over
Loss of programmed cell death 4 induces apoptosis by promoting the translation of procaspase-3 mRNA.
- Source :
- Cell Death & Differentiation; Apr2012, Vol. 19 Issue 4, p573-581, 9p
- Publication Year :
- 2012
-
Abstract
- The programmed cell death 4 (Pdcd4), a translation inhibitor, plays an essential role in tumor suppression, but its role in apoptosis remains unclear. Here we show that Pdcd4 is a critical suppressor of apoptosis by inhibiting the translation of procaspase-3 mRNA. Pdcd4 protein decreased more rapidly through microRNA-mediated translational repression following apoptotic stimuli than did the activation of procaspase-3, cleavage of poly(ADP)ribose polymerase (PARP) by active caspase-3, and nuclear fragmentation. Strikingly, the loss of Pdcd4 by the specific RNA interference increased procaspase-3 expression, leading to its activation and PARP cleavage even without apoptotic stimuli, and sensitized the cells to apoptosis. Thus, our findings provide insight into a novel mechanism for Pdcd4 as a regulator of apoptosis. [ABSTRACT FROM AUTHOR]
- Subjects :
- APOPTOSIS
CELL death
MESSENGER RNA
RNA interference
TUMORS
Subjects
Details
- Language :
- English
- ISSN :
- 13509047
- Volume :
- 19
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Cell Death & Differentiation
- Publication Type :
- Academic Journal
- Accession number :
- 73047694
- Full Text :
- https://doi.org/10.1038/cdd.2011.126