Back to Search
Start Over
Allergic contact dermatitis to various salols (phenyl salicylates).
- Source :
- Archives of Dermatological Research; Feb1982, Vol. 272 Issue 1/2, p61-66, 6p
- Publication Year :
- 1982
-
Abstract
- Patients sensitive to phenyl salicylate (salol) were patch-tested to several aryl salicylates. The most powerful derivative was p-nitrophenyl salicylate (compound 5). This can be explained by an unusually good interaction with protein (nucleophilic substitution on the carboxyl carbon). All these results were confirmed by experimental sensitization of guinea pigs to salol and cross-reaction to substituted salols. The results are in line with current theory of allergic contact dermatitis, i.e., an in vivo formation of a hapten-protein conjugate. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03403696
- Volume :
- 272
- Issue :
- 1/2
- Database :
- Complementary Index
- Journal :
- Archives of Dermatological Research
- Publication Type :
- Academic Journal
- Accession number :
- 72923556
- Full Text :
- https://doi.org/10.1007/BF00510394