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Increased expression of HB-EGF and its receptor erbB4/HER4 in accelerated anti-GBM disease.
- Source :
- Nephrology; Oct2002, Vol. 7 Issue 5, p233-238, 6p
- Publication Year :
- 2002
-
Abstract
- SUMMARY: In the kidney, heparin-binding epidermal growth factor-like growth factor (HB-EGF) and its receptors, epidermal growth factor–receptor (EGF-R) and human epidermal receptor 4 (erbB4/ HER4), may be important in the response of cells to tissue injury. To further define the role of HB-EGF, we have determined its distribution in the accelerated anti-GBM model of kidney disease. Within the glomerulus, immunohistochemical staining showed increased HB-EGF expression in podocytes and infiltrating macrophages. This was associated with strong de novo expression of erbB4/HER4 on podocytes. These data suggest that increased expression of HB-EGF and erbB4/HER4 is a response to inflammation in the glomerulus in accelerated anti-GBM disease. To determine the potential role of HB-EGF in anti-GBM disease, a blocking monoclonal antibody against HB-EGF (DE10) was administered by intravenous injection. There was, however, no significant difference in the extent of 24 h urinary protein, renal function, or histological appearances. The effects of blocking HB-EGF, therefore, may be masked by the redundancy in the EGF growth factor family. [ABSTRACT FROM AUTHOR]
- Subjects :
- EPIDERMAL growth factor
PROTEINURIA
BASAL lamina
Subjects
Details
- Language :
- English
- ISSN :
- 13205358
- Volume :
- 7
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 7265426
- Full Text :
- https://doi.org/10.1046/j.1440-1797.2002.00113.x