The role of the immune system in establishment of herpes simplex virus latency - studies using CD4 T-cell depleted mice.

The immunological mechanisms involved in establishment of herpes simplex virus (HSV) latency were studied in normal and CD4 T-cell depleted C57BL/6J mice following intravaginal infection. During transition from acute to latent ganglionic infection two consecutive processes were observed: first, clearance of infectious virus from the ganglia, and second, reduction of the number of infected ganglia. [ABSTRACT FROM AUTHOR]