Evaluation of the synergetic radio-chemotherapy effects of the radio labelled cisplatin for the treatment of glioma.

The proposal of this work was to investigate the effect of the radioactive (NH)PtCl, cis-diamminedichloroplatinum (II) or CDDP* on malignant glioma cells and verify if the low-dose continuous internal radio-chemotherapy would be able to produce additive effects. The antitumoral activity of CDDP* and the non labeled cisplatin, CDDP, were evaluated in glioblastoma. Cisplatin was cytotoxic for glioblastoma cells in a dose dependent manner. Treatment with CDDP*, (IC = 1.75 ± 0.07 μM), proved to be more potent than using just CDDP, (IC = 4.96 ± 0.40 μM). These results suggest that cisplatin is a very potent radiosensitizer evoking a supra additive effect. Internal radio-chemotherapy treatment based on CDDP* may be useful alternative to reduce the drug concentration required for effective inhibition of glioblastoma growth. [ABSTRACT FROM AUTHOR]