High dose gammaglobulin therapy in adults with idiopathic thrombocytopenic purpura (ITP) clinical effects.

This study of the effect of high-dose intravenous gammaglobulins with one or two courses of therapy in 18 adults with idiopathic thrombocytopenia purpura showed a platelet rise in thirteen patients. The highest response rates were seen in splenectomized adults. In chronic patients the response was transient only. If therapy was effective, increased values of platelet-associated IgG were reduced, while shortened platelet survival times were prolonged. There was no influence of high-dose gammaglobulins on platelet function. Different 7S-preparations such as β-propiolactone modified Ig, pH 4 treated Ig and reduced and alkylated Ig have comparable effects. [ABSTRACT FROM AUTHOR]