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Concentration of meropenem in serum and in bronchial secretions in patients undergoing fibreoptic bronchoscopy.
- Source :
- European Journal of Clinical Pharmacology; 1994, Vol. 46 Issue 1, p87-88, 2p
- Publication Year :
- 1994
-
Abstract
- The objective of the study was to evaluate the ability of meropenem to reach the bronchial lumen. 24 patients undergoing fibreoptic bronchoscopy for exploratory purposes were given a single dose of meropenem 1 g as an (i.v.), infusion over 30 min. Plasma (P) sampling times were: 0, 0.5, 1, 2 and 3 h. Bronchial secretions (BS) were collected by fibreoptic bronchoscopy at the same sampling times (except for 0 and 0.5 h) in three groups of 8 patients. Meropenem was measured by bioassay using E. coli ATCC 39118 as the test-organism. The results showed that meropenem had reached a high plasma concentration at the first sampling time (59.8 mg · 1) and then the plasma level decreased rapidly to 10.6 mg · 1 and 2.7 mg · 1 at 2 and 3 h respectively. The highest concentration achieved in bronchial secretion was 0.53 mg · 1 in the third hour, ie 20% of the serum level. The data indicate significant penetration of meropenem into bronchial secretions and achievement of a local level sufficiently high to eradicate most respiratory pathogens. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00316970
- Volume :
- 46
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Clinical Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 72386350
- Full Text :
- https://doi.org/10.1007/BF00195922