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Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times.

Authors :
Tett, S.
Cutler, D.
Source :
European Journal of Clinical Pharmacology; 1987, Vol. 31 Issue 6, p729-731, 3p
Publication Year :
1986

Abstract

We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are collected over a short period or if they are assayed with a method of low sensitivity. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00316970
Volume :
31
Issue :
6
Database :
Complementary Index
Journal :
European Journal of Clinical Pharmacology
Publication Type :
Academic Journal
Accession number :
72384325
Full Text :
https://doi.org/10.1007/BF00541305