Pharmacokinetics of tolamolol in the treatment of hypertension.

Tolamolol was administered in a 'double-blind' study to fifteen hypertensive patients by dose-titration against arterial blood pressure. Mean steady-state plasma tolamolol concentrations (C) were determined for each patient from the area under the plasma concentration - time curve during a dosage interval whilst patients were receiving optimal tolamolol doses. No significant correlation was observed between daily tolamolol dose and C; the relationship between fall in lying mean arterial pressure and C also failed to reach conventional levels of statistical significance, but C was observed to be correlated with the fall in standing pressure. The results suggest that plasma concentrations in excess of 200 ng/ml may be required to achieve an effective hypotensive response with the drug. [ABSTRACT FROM AUTHOR]