"A novel in vivo model for the study of human breast cancer metastasis using primary breast tumor-initiating cells from patient biopsies"

The article focuses on a study which aims developing a novel in vivo and reproducible breast cancer model using breast tumor-initiating cells (bTICs). The model was developed by isolating bTICs as tumorspheres from biopsies for the investigation of breast cancer metastatic process. It explains the methodology of the study, in which culture conditions were transplanted into the mammary fat pad of mice. It concludes the efficiency of this model for investigating breast cancer metastasis.