The effect of smoking on the bioavailability of metronidazole in plasma and saliva.

Authors :: Montalli, Victor Angelo
de Cassia Bergamaschi, Cristiane
Ramacciato, Juliana Cama
Nolasco, Fabiana Pinchetti
Groppo, Francisco Carlos
de Brito Jr., Rui Barbosa
Haas, Daniel A.
Motta, Rogerio Heladio Lopes
Source :: Journal of the American Dental Association (JADA); Feb2012, Vol. 143 Issue 2, p149-156, 8p
Publication Year :: 2012
Abstract: The article presents a study which investigates on the relation of cigarette smoking in the bioavailability of metronidazole in plasma and saliva. The study was conducted to 13 nonsmokers who received single oral dose of 750 milligrams of metronidazole and used high-performance liquid chromatography (HPLC) to quantify the concentrates of metronidazole in plasma and saliva. The study reveals reduction in plasma concentration in smokers compared nonsmokers.

Subjects :: PERIODONTAL disease diagnosis
RISK factors of periodontal disease
ACADEMIC medical centers
BIOAVAILABILITY
CHROMATOGRAPHIC analysis
DENTISTRY
CLINICAL drug trials
METRONIDAZOLE
EVALUATION of medical care
SALIVA
SMOKING
PHARMACODYNAMICS

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