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Influence of B vitamins on binding properties of serotonin receptors in the CNS of rats.
- Source :
- Klinische Wochenschrift; Jan1990, Vol. 68 Issue 2, p142-145, 4p
- Publication Year :
- 1990
-
Abstract
- Treatment of normal adult rats with pyridoxine or a B-vitamin mixture resembling Neurobion 1 led to an increase in serotonin content of various brain areas and to a decrease in the number of serotonin S receptors. The results indicate that the pyridoxal phosphate level in regions of the brain regulates the extent of decarboxylation of 5-hydroxytryptophan, the precursor of serotonin. The results also suggest a continuum from deficiency in pyridoxine to treatment of animals with a moderate excess of pyridoxine which is reflected in the synthesis and secretion into the synaptic cleft of the neurotransmitter serotonin. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00232173
- Volume :
- 68
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Klinische Wochenschrift
- Publication Type :
- Academic Journal
- Accession number :
- 72317407
- Full Text :
- https://doi.org/10.1007/BF01646863