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Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.
- Source :
- Nature Genetics; Mar2012, Vol. 44 Issue 3, p247-250, 4p, 2 Charts, 1 Graph
- Publication Year :
- 2012
-
Abstract
- Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10<superscript>?8</superscript>), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10<superscript>?8</superscript>). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases. [ABSTRACT FROM AUTHOR]
- Subjects :
- DISEASE susceptibility
SCHIZOPHRENIA
GENETICS
GENOMES
CENTRAL nervous system
Subjects
Details
- Language :
- English
- ISSN :
- 10614036
- Volume :
- 44
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Nature Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 71965770
- Full Text :
- https://doi.org/10.1038/ng.1108