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[2.2]Paracyclophane-Derived Planar-Chiral Hydrogen-Bond Receptors.
- Source :
- Israel Journal of Chemistry; Feb2012, Vol. 52 Issue 1/2, p76-91, 16p, 32 Diagrams, 1 Chart
- Publication Year :
- 2012
-
Abstract
- The development of planar-chiral hydrogen-bond donors based on the [2.2]paracyclophane scaffold is discussed. General strategies to access functionalized enantiopure [2.2]paracyclophane derivatives are briefly reviewed, with the focus on suitable precursors for the synthesis of planar-chiral thiourea derivatives. The synthesis of fourteen hydrogen-bond donors is described. The interaction of four thiourea derivatives with hydrogen-bond acceptors (DMSO and tetramethylammonium chloride) was investigated by <superscript>1</superscript>H NMR spectroscopy and X-ray crystallography. A selection of enantiomerically pure planar-chiral derivatives was applied in asymmetric hydrogen-bond catalysis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00212148
- Volume :
- 52
- Issue :
- 1/2
- Database :
- Complementary Index
- Journal :
- Israel Journal of Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 71885306
- Full Text :
- https://doi.org/10.1002/ijch.201100082