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Murine Schnurri-2 controls natural killer cell function and lymphoma development.
- Source :
- Leukemia & Lymphoma; Mar2012, Vol. 53 Issue 3, p479-486, 8p, 5 Graphs
- Publication Year :
- 2012
-
Abstract
- Schnurri (Shn)-2 is a large zinc finger-containing protein implicated in cell growth, signal transduction and lymphocyte development. Here, we report that Shn-2-deficient ( Shn-2<superscript>−//−</superscript>) mice develop CD3-positive lymphoma spontaneously. In Shn-2<superscript>−//−</superscript> mice, we observed decreased cytotoxicity of natural killer (NK) cells accompanied by decreased expression of perforin and granzyme-B. In addition, phosphorylation of signal transducer and activator of transcription (STAT) 5 was reduced in Shn-2<superscript>−//−</superscript> NK cells, while phosphorylation of STAT3 and protein expression of nuclear factor-κB p65 subunit were enhanced in Shn-2<superscript>−//−</superscript> NK cells. Moreover, cell-surface expression of activation molecules such as CD27, CD69 and CD122 were decreased on Shn-2<superscript>−//−</superscript> NK cells. Thus, Shn-2 is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10428194
- Volume :
- 53
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Leukemia & Lymphoma
- Publication Type :
- Academic Journal
- Accession number :
- 71833550
- Full Text :
- https://doi.org/10.3109/10428194.2011.625099