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Fyn is not essential for Bcr-Abl-induced leukemogenesis in mouse bone marrow transplantation models.
- Source :
- International Journal of Hematology; Feb2012, Vol. 95 Issue 2, p167-175, 9p
- Publication Year :
- 2012
-
Abstract
- The Bcr-Abl oncogene causes human Philadelphia chromosome-positive (Ph) leukemias, including B-cell acute lymphoblastic leukemia (B-ALL) and chronic myeloid leukemia (CML) with chronic phase (CML-CP) to blast crisis (CML-BC). Previous studies have demonstrated that Src family kinases are required for the induction of B-ALL, but not for CML, which is induced by Bcr-Abl in mice. In contrast, it has been reported that Fyn is up-regulated in human CML-BC compared with CML-CP, implicating Fyn in the blast crisis transition. Here, we aimed to delineate the exact role of Fyn in the induction/progression of Ph leukemias. We found that Fyn is expressed in mouse hematopoietic cells at varying stages of development, including c-kitSca-1Lin cells. Notably, Fyn is highly expressed in some of human lymphomas, but not in human Ph leukemias including CML-BC. In mouse bone marrow transplantation models, mice transplanted with wild-type or Fyn-deficient bone marrow cells transduced with Bcr-Abl showed no differences in the development of B-ALL or CML-like diseases. Similarly, Fyn deficiency failed to impact the development of myeloid CML-BC induced by Bcr-Abl and Hes1. Elevated expression of Fyn was not found in mouse samples of Bcr-Abl-mediated CML- and CML-BC-like diseases. Thus, Fyn is not required for the pathogenesis of Bcr-Abl-mediated leukemias. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09255710
- Volume :
- 95
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- International Journal of Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 71749018
- Full Text :
- https://doi.org/10.1007/s12185-011-0994-5