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Association between Antimicrobial Resistance among Pneumococcal Isolates and Burden of Invasive Pneumococcal Disease in the Community.
- Source :
- Clinical Infectious Diseases; 8/15/2002, Vol. 35 Issue 4, p420, 8p
- Publication Year :
- 2002
-
Abstract
- Treatment of infections with drug-resistant strains of Streptococcus pneumoniae (pneumococcus) may fail; whether drug resistance is associated with an increase in the number of serious infections in the community is unknown. We evaluated the relationship between the proportion of antimicrobial-resistant S. pneumoniae isolates and the number of cases of invasive pneumococcal disease. Linear regression models included 1996 county-level data from 38 counties participating in the US Centers for Disease Control and Prevention's Active Bacterial Core Surveillance. Separate models evaluated hospitalized children aged <5 years, nonhospitalized children aged <5 years, adults aged 18-64 years, and adults aged >64 years. The proportion of isolates resistant to ≥3 drug classes was associated with invasive disease in both hospitalized (P = .06) and nonhospitalized (P = .001) children. The proportion of multidrug-resistant pneumococcal isolates did not predict invasive cases among adults. The increasing prevalence of multidrug-resistant pneumococci among children may be leading to an increase in invasive disease. [ABSTRACT FROM AUTHOR]
- Subjects :
- STREPTOCOCCUS pneumoniae
INFECTION treatment
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 35
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 7156968
- Full Text :
- https://doi.org/10.1086/341897