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Effects of ethnicity and vitamin D supplementation on vitamin D status and changes in bone mineral content in infants.

Authors :
Abrams, Steven A.
Hawthorne, Keli M.
Rogers, Stefanie P.
Hicks, Penni D.
Carpenter, Thomas O.
Source :
BMC Pediatrics; 2012, Vol. 12 Issue 1, p1-7, 7p, 1 Chart, 2 Graphs
Publication Year :
2012

Abstract

Background: To evaluate the effects on serum 25(OH)D and bone mineralization of supplementation of breast-fed Hispanic and non-Hispanic Caucasian infants with vitamin D in infants in Houston, Texas. Methods: We measured cord serum 25(OH)D levels, bone mineral content (BMC), bone mineral density (BMD) and their changes over 3 months of life with 400 IU/day of vitamin D3 supplementation. Results: Cord serum 25(OH)D was significantly lower in Hispanic than non-Hispanic Caucasian infants (16.4 ± 6.5 ng/mL, n = 27, vs 22.3 ± 9.4 n = 22, p = 0.013). Among 38 infants who completed a 3 month vitamin D supplementation intervention, provision of 400 IU/day of vitamin D increased final 25(OH)D to a higher level in non-Hispanic Caucasian compared to Hispanic infants. There was no significant relationship between cord serum 25(OH)D and BMC or BMD in the first week of life (n = 49) or after 3 months of vitamin D supplementation. Conclusion: Low cord 25(OH)D levels are seen in Hispanic infants, but their functional significance is uncertain related to bone health in a southern US setting. Daily vitamin D intake of 400 IU during the first months of life appears adequate to increase serum 25(OH)D and support BMC increases despite low initial 25(OH)D levels in some infants. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14712431
Volume :
12
Issue :
1
Database :
Complementary Index
Journal :
BMC Pediatrics
Publication Type :
Academic Journal
Accession number :
71340708
Full Text :
https://doi.org/10.1186/1471-2431-12-6