Decreased levels of coenzyme Q10 in patients with bronchial asthma.

Background: The contribution of free oxygen radicals in the pathogenesis of bronchial asthma is generally accepted. The modulation of antioxidative defence by supplementation with antioxidants represents additive therapy in complex management of disease. The aim of the study was to assess the levels of coenzyme Q₁₀ , α-tocopherol, and β-carotene both in plasma and whole blood, and malondialdehyde (MDA) and eosinophil cationic protein (ECP) in plasma of asthmatics (As). Methods: Fifty-six As (15 males and 41 females) aged from 19 to 72 years (mean age 46 years) suffering from allergic asthma were enrolled into the study. The control group comprised 25 healthy volunteers (16 males, 9 females) aged 25–50 years. Results: The concentrations of CoQ₁₀ decreased significantly both in plasma and whole blood, compared with healthy volunteers (0.34 ± 0.15 μmol/l vs. 0.52 ± 0.15 μmol/l, 0.33 ± 0.14 μmol/l vs. 0.50 ± 0.13 μmol/l, P < 0.001, P < 0.001, respectively). The levels of α-tocopherol were decreased both in plasma and whole blood in comparison with controls [24.10 μmol/l (19.8; 30.5), vs. 33.20 μmol/l (28.25; 38.05), 17.22 ± 6.45 μmol/l vs. 21.58 ± 7.92 μmol/l, P = 0.006, P = 0.01, respectively]. The levels of MDA were elevated over the reference range in both groups (reference range < 4.5 μmol/l). No changes were seen in β-carotene concentrations. Positive correlation was found between whole blood CoQ ₁₀ and α-tocopherol concentrations. Conclusion: Results of the study suggest a possible contribution of suboptimal concentrations of CoQ₁₀ on antioxidative dysbalance in As and provide a rationale for its supplementation. [ABSTRACT FROM AUTHOR]