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Evaluation of the Anti-Inflammatory Effect of Milk Fermented by a Strain of IL-10-Producing Lactococcus lactis Using a Murine Model of Crohn's Disease.
- Source :
- Journal of Molecular Microbiology & Biotechnology; 2012, Vol. 21 Issue 3/4, p138-146, 9p, 1 Chart, 3 Graphs
- Publication Year :
- 2012
-
Abstract
- Interleukin-10 (IL-10) is the most important anti-inflammatory cytokine at intestinal level, and its absence is involved in inflammatory bowel diseases. However, oral treatment with IL-10 is difficult because of its low survival in the gastrointestinal tract and systemic treatments lead to undesirable side effects. The aim of this paper was to evaluate the anti-inflammatory effect of the administration of milks fermented by Lactococcus lactis strains that produce IL-10 under the control of the xylose-inducible expression system using a trinitrobenzenesulfonic acid-induced colitis murine model. Mice that received milks fermented by L. lactis strains producing IL-10 in the cytoplasm (Cyt strain) or secreted to the product (Sec strain) showed lower damage scores in their large intestines, decreased IFN-γ levels in their intestinal fluids and lower microbial translocation to liver, compared to mice receiving milk fermented by the wild-type strain or those not receiving any treatment. The results obtained in this study show that the employment of fermented milks as a new form of administration of IL-10-producing L. lactisis effective in the prevention of inflammatory bowel disease in a murine model. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14641801
- Volume :
- 21
- Issue :
- 3/4
- Database :
- Complementary Index
- Journal :
- Journal of Molecular Microbiology & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 70859057
- Full Text :
- https://doi.org/10.1159/000333830