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Modification of glycosylated haemoglobin concentration during artificial endocrine pancreas treatment of diabetics.
- Source :
- Diabetologia; Feb1980, Vol. 18 Issue 2, p125-130, 6p
- Publication Year :
- 1980
-
Abstract
- In order to verify whether or not insulininduced blood glucose control can acutely lower glycosylated haemoglobin levels, HbA (HbAI) was measured in 11 diabetics before, during and after 3 days of treatment with an 'artificial endocrine pancreas' (Biostator). Initially 5 patients were in fair glycaemic control (group A), while the other 6 showed poor control (group B). HbAI levels decreased significantly after 3 days in both groups A (from 9.6 ± 0.2% to 8.5 ± 0.3%, mean ± SEM, p < 0.05) and B (from 13.7 ± 0.2% to 12.6 ± 0.3%, p < 0.05). A further HbAI decrease was observed until day 60 following Biostator treatment, during which period glycaemic control inproved, as assessed by fasting and post-lunch plasma glucose values and daily glycosuria determined every 10 days. These results suggest that increased HbAI levels may be reversed early by strict blood glucose control during a 3 day period. It is concluded that HbAI levels not only reflect long-term glycaemic control, but also recent acute variations in mean blood glucose values. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0012186X
- Volume :
- 18
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Diabetologia
- Publication Type :
- Academic Journal
- Accession number :
- 70806731
- Full Text :
- https://doi.org/10.1007/BF00290488