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The Muridae glyceraldehyde-3-phosphate dehydrogenase family.
- Source :
- Journal of Molecular Evolution; 1989, Vol. 29 Issue 3, p212-222, 11p
- Publication Year :
- 1989
-
Abstract
- Although only one gene is known to be functional, numerous glyceraldehyde-3-phosphate dehydrogenase (GAPDH) related sequences are scattered throughout Mus musculus and Rattus rattus genomes. In this report we show that: (1) GAPDH pseudogenes are repeated to comparable extents, at least 400 copies, in 12 other Muridae species; (2) the complete, or nearly so, sequence of GAPDH messenger RNA is amplified, and a high proportion, if not all of these copies, are intronless; (3) GAPDH pseudogenes are preferentially located in heavily methylated and DNAse I-insensitive regions of chromatin; and (4) the presence of atypical GAPDH-related mRNAs in different cellular contexts raises the possibility that more than one GAPDH gene is transcribed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00222844
- Volume :
- 29
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Molecular Evolution
- Publication Type :
- Academic Journal
- Accession number :
- 70630594
- Full Text :
- https://doi.org/10.1007/BF02100205