Back to Search
Start Over
Impact of New Chemotherapeutic and Targeted Agents on Survival in Stage IV Non-Small Cell Lung Cancer.
- Source :
- Oncologist; Sep2011, Vol. 16 Issue 9, p1307-1315, 9p, 4 Charts, 2 Graphs
- Publication Year :
- 2011
-
Abstract
- Purpose. Significant advances in the systemic management of metastatic non-small cell lung cancer (NSCLC) have occurred over the past decade, with options now including multiple lines of chemotherapy, epidermal growth factor receptor inhibitors, and antiangiogenic agents. Improvements in overall survival have been demonstrated in randomized controlled trials comparing these newer agents with best supportive care or standard therapy. This study examined uptake of these therapies in general practice and their impact on survival. Methods. This retrospective cohort study compared demographic, treatment, and survival data among 987 patients diagnosed with stage IV NSCLC at two institutions in 1998, 2003, and 2008. Cohorts were selected based on intervals when doublet chemotherapy, second-line chemotherapy, and targeted agents were incorporated into the standard treatment regimen. Results. The proportion of patients receiving systemic therapy increased over time (20% in 1998, 42% in 2008). Overall survival improved significantly across cohorts (p<.001), with 2-year survival rates of 0.3% in 1998, 4% in 2003, and 15% in 2008. In amultivariate survival analysis, the 2003 and 2008 cohorts were independently associated with longer survival, as was the use of one or more lines of systemic therapy. Elderly patients (aged ≥70 years) were also more likely to receive systemic therapy over time, with longer overall survival (p < .001). Conclusion. Over the past decade, there has been an increasing use of systemic therapy in stage IV NSCLC patients, including the elderly. This has been associated with significantly longer overall survival. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANALYSIS of variance
CHI-squared test
DRUG prescribing
LUNG cancer
EVALUATION of medical care
METASTASIS
SMOKING
SURVIVAL analysis (Biometry)
EXPERIMENTAL therapeutics
TIME
DRUG development
PHYSICIAN practice patterns
PROPORTIONAL hazards models
RETROSPECTIVE studies
DATA analysis software
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 10837159
- Volume :
- 16
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Oncologist
- Publication Type :
- Academic Journal
- Accession number :
- 70241382
- Full Text :
- https://doi.org/10.1634/theoncologist.2011-0079