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Sox9 Is Upstream of MicroRNA-140 in Cartilage.
- Source :
- Applied Biochemistry & Biotechnology; Jan2012, Vol. 166 Issue 1, p64-71, 8p
- Publication Year :
- 2012
-
Abstract
- MicroRNA-140 (miR-140) is specifically expressed in developing cartilage tissues. We have previously reported that miR-140 plays an important role during palatal cartilage development by modulating platelet- derived growth factor receptor alpha ( pdgfra) in zebrafish. However, the regulatory mechanism of miR-140 in cartilage is still unknown. Using developing zebrafish, sox9a mutant ( sox9a−/−) and sox9b mutant ( sox9b−/−) zebrafish and SOX9 small interfering RNA in human chondrocytes, T/C-28 cells, we found that miR-140 is regulated by the cartilage master transcription regulator Sox9 in zebrafish and mammalian cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02732289
- Volume :
- 166
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Applied Biochemistry & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 70129584
- Full Text :
- https://doi.org/10.1007/s12010-011-9404-y