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Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats.
- Source :
- Journal of Nutrition; Jul2002, Vol. 132 Issue 7, p1969-1976, 8p, 6 Charts, 2 Graphs
- Publication Year :
- 2002
-
Abstract
- Apples may have selective effects on abnormalities associated with the plurimetabolic syndrome. Therefore, the effects of 20% lyophilized apple supplementation on plasma and tissue lipids and on protection against susceptibility to oxidative stress and renal dysfunction were investigated in Zucker lean (Fa/-) or obese (fa/fa) rats. The experimental diets were equilibrated for sugar supply, contained 0.25 g/100 g cholesterol and provided only one third of the vitamin E requirement. Obese Zucker rats were hypercholesterolemic with cholesterol accumulation in LDL and HDL fractions. The apple diet lowered plasma and LDL cholesterol (-22 and -70%, respectively, P < 0.01) in obese Zucker rats and, in parallel, reduced triglyceride accumulation in heart and liver. Zucker rats fed the apple diet also had a larger intestinal pool and greater fecal excretion of bile acids. The heart concentration and urinary excretion of malondialdehyde were reduced by apple consumption in obese Zucker rats, suggesting better protection against peroxidation. Glucosuria and proteinuria in obese Zucker rats were also suppressed by the apple diet. In conclusion, despite their moderate fiber content, apples improve substantially the lipid status and peroxidative parameters in obese Zucker rats, suggesting that other plant constituents such as polyphenols are involved in these effects. [ABSTRACT FROM AUTHOR]
- Subjects :
- APPLES
CHOLESTEROL
RATS
HYPERCHOLESTEREMIA prevention
ANIMAL experimentation
ANTHROPOMETRY
ANTIOXIDANTS
BODY weight
COMPARATIVE studies
DIET
DIGESTION
CHOLESTEROL content of food
FREEZE-drying
GENETIC disorders
INGESTION
KIDNEYS
LIPIDS
LIPID metabolism disorders
RESEARCH methodology
MEDICAL cooperation
OBESITY
RESEARCH
OXIDATIVE stress
EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00223166
- Volume :
- 132
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 7000926
- Full Text :
- https://doi.org/10.1093/jn/132.7.1969