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Liver Injury and Its Molecular Mechanisms in Mice Caused by Exposure to Cerium Chloride.
- Source :
- Archives of Environmental Contamination & Toxicology; Jan2012, Vol. 62 Issue 1, p154-164, 11p
- Publication Year :
- 2012
-
Abstract
- Cerium has been demonstrated to damage liver of mice, but very little is known about the molecular mechanisms underlying the mouse liver apoptosis. In order to understand the liver injury induced by intragastric administration of cerium chloride (CeCl) for 60 consecutive days, the hepatocyte ultrasrtucture, various oxidative stress parameters, and the stress-related gene expression levels were investigated for the mouse liver. The results demonstrated that CeCl had an obvious accumulation in the mouse liver, leading to a classical laddering cleavage of DNA and hepatocyte apoptosis. CeCl significantly promoted the accumulation of reactive oxygen species and inhibited the stress-related gene expression of superoxide dismutase, catalase, glutathione peroxidase, metallothionein, heat-shock protein 70, glutathione- S-transferase, P53, and transferring, and it effectively activated the cytochrome p450 1A. It implied that CeCl resulted in apoptosis and alteration of expression levels of the genes related with metal detoxification/metabolism regulation and radical scavenging action in mice. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00904341
- Volume :
- 62
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Archives of Environmental Contamination & Toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 69970255
- Full Text :
- https://doi.org/10.1007/s00244-011-9672-0