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Low-dose combined therapy with fluvastatin and cholestyramine in hyperlipidemic patients.
- Source :
- Annals of Internal Medicine; 4/1/94, Vol. 120 Issue 7, p537-543, 7p
- Publication Year :
- 1994
-
Abstract
- <bold>Objective: </bold>To compare the low-density lipoprotein (LDL) cholesterol-lowering efficacy of low-dose combinations of cholestyramine and fluvastatin.<bold>Design: </bold>Randomized, double-blind, parallel group, placebo-controlled trial with a 24-week double-blind treatment period divided into three phases.<bold>Setting: </bold>Office-based clinics.<bold>Patients: </bold>Hypercholesterolemic, with LDL cholesterol of 4.14 mmol/L or greater (> or = 160 mg/dL) and plasma triglycerides of 3.39 mmol/L or less (< or = 300 mg/dL). Four hundred sixty patients were screened; 224 patients were randomized into a double-blind treatment period; 203 completed the study; 6 dropped out because of adverse events.<bold>Intervention: </bold>Patients were treated with 10 mg or 20 mg of fluvastatin alone, 8 g or 16 g of cholestyramine alone, or combinations of these fluvastatin and cholestyramine dosages (six treatment groups).<bold>Measurements: </bold>Changes in lipid variables, particularly LDL cholesterol.<bold>Results: </bold>The 10-mg and 20-mg fluvastatin monotherapy groups showed considerable reductions in LDL cholesterol initially (-20.1% [SD, 8.8%] and -20.2% [SD, 10.1%], respectively); these reductions were maintained. Reductions in LDL cholesterol that resulted from the addition of cholestyramine, 8 g/d, to 10 mg of fluvastatin and 20 mg of fluvastatin were greater than those observed with monotherapy (10-mg fluvastatin--[10-mg fluvastatin plus cholestyramine], 9.1%; 95% CI, 3.8% to 14.4%) and 20-mg fluvastatin--[20-mg fluvastatin plus cholestyramine], 11.6%; CI, 6.5% to 16.8%). The increase in cholestyramine dose to 16 g/d in the three combination groups provided only a modest additional response.<bold>Conclusions: </bold>Low-density lipoprotein cholesterol reductions of about 25% to 30% can be achieved with low-dose combination therapy with fluvastatin and cholestyramine. The addition of low-dose resin appears to produce greater overall cholesterol reduction than does a simple doubling of the fluvastatin dosage. The low-dose combination treatment was highly successful in achieving the goals of the National Cholesterol Education Program guidelines. [ABSTRACT FROM AUTHOR]
- Subjects :
- LOW density lipoproteins
ANTICHOLESTEREMIC agents
HYPERLIPIDEMIA
PATIENTS
Subjects
Details
- Language :
- English
- ISSN :
- 00034819
- Volume :
- 120
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Annals of Internal Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 6989142
- Full Text :
- https://doi.org/10.7326/0003-4819-120-7-199404010-00002