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Influence of brain-derived neurotrophic factor and catechol O-methyl transferase polymorphisms on effects of meditation on plasma catecholamines and stress.
- Source :
- Stress: The International Journal on the Biology of Stress; Jan2012, Vol. 15 Issue 1, p97-104, 8p
- Publication Year :
- 2012
-
Abstract
- Meditation may show differential effects on stress and plasma catecholamines based on genetic polymorphisms in brain-derived neurotrophic factor (BDNF) and catechol O-methyl transferase (COMT). Eighty adults (40 men, 40 women; mean age 26 years) who practiced meditation regularly and 57 healthy control adults (35 men, 22 women; mean age 26 years) participated. Plasma catecholamines (norepinephrine (NE), epinephrine (E), and dopamine (DA)) concentrations were measured, and a modified form of the Stress Response Inventory was administered. The results were analyzed using two-way analysis of covariance (ANCOVA) with control and meditation subjects, gene polymorphism as factors, and meditation duration as the covariate. Two-way ANCOVA showed a significant interaction between control and meditation subjects, and BDNF Val66Met polymorphism on DA/NE++DA/E ( p == 0.042) and NE/E++NE/DA ( p == 0.046) ratios. A significant interaction was found for control and meditation subjects with COMT Val158Met polymorphism and plasma NE concentrations ( p == 0.009). Post hoc ANCOVA in the meditation group, adjusted for meditation duration, showed significantly higher plasma NE concentrations for COMT Met carriers than COMT Val/Val subjects ( p == 0.025). Significant differences of stress levels were found between the control and meditation subjects in BDNF Val/Met ( p < 0.001) and BDNF Met/Met ( p == 0.003), whereas stress levels in the BDNF Val/Val genotype did not differ between the control and meditation groups. This is the first evidence that meditation produces different effects on plasma catecholamines according to BDNF or COMT polymorphisms. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10253890
- Volume :
- 15
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Stress: The International Journal on the Biology of Stress
- Publication Type :
- Academic Journal
- Accession number :
- 69686580
- Full Text :
- https://doi.org/10.3109/10253890.2011.592880