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TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.

Authors :
Pasparakis, Manolis
Courtois, Gilles
Hafner, Martin
Smidt-Supprian, Marc
Nenci, Arianna
Toksoy, Atiye
Krampert, Monica
Goebeler, Matthias
Gillitzer, Reinhard
Israel, Alain
Krieg, Thomas
Rajewsky, Klaus
Haase, Ingo
Source :
Nature; 6/20/2002, Vol. 417 Issue 6891, p861, 6p, 1 Color Photograph, 3 Diagrams, 16 Graphs
Publication Year :
2002

Abstract

Presents a study that investigated the function of I κ B kinase 2 (IKK2) specifically in epidermal keratinocytes using Cre/loxP-mediated gene targeting. Effect of IKK2 deficiency; Effect of epidermis-specific deletion of IKK2 on mice; Function of IKK2-mediated NF- κ B activity in epidermal keratinocytes.

Details

Language :
English
ISSN :
00280836
Volume :
417
Issue :
6891
Database :
Complementary Index
Journal :
Nature
Publication Type :
Academic Journal
Accession number :
6907927
Full Text :
https://doi.org/10.1038/nature00820