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Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents.
- Source :
- Molecules; Mar2011, Vol. 16 Issue 3, p2519-2526, 8p, 1 Diagram, 1 Chart
- Publication Year :
- 2011
-
Abstract
- Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by <superscript>1</superscript>H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3) . Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTINEOPLASTIC agents
CELL lines
LUNG cancer
COLON cancer
BREAST cancer
DOXORUBICIN
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 16
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 68631710
- Full Text :
- https://doi.org/10.3390/molecules16032519