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Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants.
- Source :
- Journal of Biomedical Materials Research, Part A; Jan2011, Vol. 96A Issue 1, p230-238, 9p
- Publication Year :
- 2011
-
Abstract
- We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2010. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15493296
- Volume :
- 96A
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Biomedical Materials Research, Part A
- Publication Type :
- Academic Journal
- Accession number :
- 67672456
- Full Text :
- https://doi.org/10.1002/jbm.a.32977