Back to Search
Start Over
A bisamide and four diketopiperazines from a marine-derived Streptomyces sp.
- Source :
- Journal of Asian Natural Products Research; Dec2011, Vol. 13 Issue 12, p1146-1150, 5p, 2 Diagrams, 2 Charts
- Publication Year :
- 2011
-
Abstract
- A new bisamide N<subscript>1</subscript>-acetyl-N<subscript>7</subscript>-phenylacetyl cadaverine (1) and a series of diketopiperazines including a new diketopiperazine cyclo(2-hydroxy-Pro-R-Leu) (2), together with a new natural product cyclo(4-hydroxy-S-Pro-S-Trp) (3) and two known leucine-based diketopiperazines cyclo(4-hydroxy-R-Pro-S-Leu) (4) and cyclo (S-Pro-R-Leu) (5), were isolated from ethyl acetate extract of a fermentation broth of a marine-derived Streptomyces sp. Their structures were elucidated by the interpretation of spectroscopic analysis. The antitumor activities of compounds 1–3 against HL-60 cell lines were tested by MTT assay. [ABSTRACT FROM AUTHOR]
- Subjects :
- FATS & oils analysis
ANTINEOPLASTIC agents
BIOPHYSICS
CELL culture
CHROMATOGRAPHIC analysis
GRAM-positive bacteria
HETEROCYCLIC compounds
HIGH performance liquid chromatography
INFRARED spectroscopy
MASS spectrometry
RESEARCH methodology
NUCLEAR magnetic resonance spectroscopy
RESEARCH funding
AQUATIC microbiology
CYTOTOXINS
ANALYTICAL chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 13
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 67457998
- Full Text :
- https://doi.org/10.1080/10286020.2011.617744