SNX-2112, a Novel Hsp90 Inhibitor, Induces G2/M Cell Cycle Arrest and Apoptosis in MCF-7 Cells.

The article presents a study regarding the effects of SNX-2112 heat shock protein 90 (Hsp90) inhibitor on the inhibition of cell growth, apoptosis, and cycle in MCF-7 human breast cancer cells. The study indicate that the SNX-2112 inhibits cell growth in a dose- and time-dependent manner based on a 3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay and flow cytometric analysis. The study has found the involve activation of mitochondrial apoptopic pathway in SNX-2112.