Prevalence of BRCA1 and BRCA2 mutations in triple negative breast cancer.

The article presents a study which examines the prevalence of breast cancer 1 (BRCA1) and breast cancer 2 (BRCA2) mutations in triple negative breast cancer (TNBC). It indicates that 11 out of 77 TNBCs unselected for age or family history had a germline mutation and one a somatic mutation in BRCA1, and three had BRCA2 mutations. It offers a guide to the probable outcome of testing in an isolated TNBC presenting for the first time in the oncology clinic.