Generation of tumor-initiating cells by exogenous delivery of OCT4 transcription factor.

The article focuses on the research related to determine the formation of tumor-initiating cells with the help of exogenous delivery of octamer-binding transcription factor 4 (OCT4) transcription factor. It offers information on tumor-initiating cells (TICs) or cancer stem cells, tumor cells with the ability of self renewing and generate tumors. It mentions that formation of TIC-like cell lines with ectopic expression of the OCT4 transcription factor (TF) in used for breast cell preparations.