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Why Don't CD8+ T Cells Reduce the Lifespan of SIV-Infected Cells In Vivo?
- Source :
- PLoS Computational Biology; Sep2011, Vol. 7 Issue 9, p1-8, 8p, 5 Graphs
- Publication Year :
- 2011
-
Abstract
- In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1553734X
- Volume :
- 7
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- PLoS Computational Biology
- Publication Type :
- Academic Journal
- Accession number :
- 66702447
- Full Text :
- https://doi.org/10.1371/journal.pcbi.1002200