Generation of retinal ganglion-like cells from reprogrammed mouse fibroblasts.

Authors :: Mengfei Chen
Qin Chen
Xuerong Sun
Wenjuan Shen
Bingqian Liu
Xiufeng Zhong
Yunxia Leng
Chunmei Li
Weizhong Zhang
Fang Chai
Bing Huang
Qianying Gao
Andy Peng Xiang
Yehong Zhuo
Jian Ge
Source :: Annals of Neurosciences; Apr2011, Vol. 18 Issue 2, p64-65, 2p
Publication Year :: 2011
Abstract: The article discusses a study of retinal ganglion-like cells from reprogrammed mouse fibroblasts. The study analyzed whether induced pluripotent stem (iPS) cells express retinal progenitor cell (RPC) related marker genes. Results of immunofluorescence and real-time polymerase chain reaction (PCR) revealed that both undifferentiated GFP-iPS-C5 and iPS-C6 cells expressed RPC-related genes. Authors also observed the formation of teratoma in the eyes of one mouse.