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Chronic idiopathic thrombocytopenia treated with immunoglobulin.
- Source :
- Archives of Disease in Childhood; Noc1983, Vol. 58 Issue 11, p851-855, 5p, 3 Charts, 4 Graphs
- Publication Year :
- 1983
-
Abstract
- Twenty five children with chronic idiopathic thrombocytopenic purpura followed from 6-96 months in 7 Italian paediatric departments were treated with high dose immunoglobulin according to a multicentre protocol. Positive responses were observed in 20 of 25 patients (80%) and negative responses in 5 of 25 (20%). On previous steroid treatment 7 of 10 positive responders were steroid resistant and 13 of 15 were steroid dependent. Within four weeks of beginning treatment 16 of 20 patients (80%) relapsed, while 4 of 20 (20%) maintained normal platelet values after 4-12 months' follow up. Statistical analysis of the platelet count on day five of treatment enabled us to divide positive responders into three groups: good, intermediate, and poor. The possible mode of action and clinical application of high dose immunoglobulin are discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00039888
- Volume :
- 58
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Archives of Disease in Childhood
- Publication Type :
- Academic Journal
- Accession number :
- 66657078
- Full Text :
- https://doi.org/10.1136/adc.58.11.851