Substituted quinolinones 15*. Preparation and enzymatic activity of some pyrazoloazines linked to the 4-hydroxy-1-methyl- quinolin-2(1 H)-one moiety.

The heterocyclization reaction of pyrazolinylquinolinone and its 4-chlorobenzylidene, 2-pyridylmethylene, pyridylaminomethylene, and 2-pyridylhydrazone derivatives with some active methylene nitriles and acrylonitriles, is described. These cyclization reactions afforded novel heterocyclic systems, such as pyrazolo[3,4-b]pyridines, pyrano[2,3- c]pyrazoles, and pyrazolo[4,3- c]pyridazines, linked to position 3 of 4-hydroxy-1-methylquinolin-2(1 H)-one. The effect of the new products on the activity of α-amylase was examined. Some pyrano[2,3- c]pyrazoles revealed significant increase in α-D-glucose production by the enzyme. [ABSTRACT FROM AUTHOR]