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Photoisomerism of a vasodilator cinepazide maleate.
- Source :
- Medicinal Chemistry Research; Nov2011, Vol. 20 Issue 8, p1154-1157, 4p
- Publication Year :
- 2011
-
Abstract
- The photoinduced tautomerisation of cinepazide maleate ( 1), an effective vasodilator widely used in clinical therapy, had been investigated. It was found that (i) the higher the concentration of cinepazide maleate ( 1), the more stable it was; (ii) the effect of light on the photoisomerism of cinepazide maleate ( 1) was obvious in a suitable wavelength (e.g., 365 nm); (iii) solvents (e.g., acetone) with carbonyl chromophore absorbing UV could inhibit the generation of cis-isomer; (iv) anthranilic acid could be used as an effective ultraviolet absorbent and (v) the cinepazide maleate ( 1) could be properly stored under the airtight, light-free and room temperature conditions. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10542523
- Volume :
- 20
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Medicinal Chemistry Research
- Publication Type :
- Academic Journal
- Accession number :
- 66222584
- Full Text :
- https://doi.org/10.1007/s00044-010-9447-6