Trimethoprim-sulfamethoxazole induced hyperkalaemia in elderly patients receiving spironolactone: nested case-control study.

The article presents a nested case-control study on the impact of Trimethoprim-sulfamethoxazole and spironolactone drugs in the occurence of hyperkalaemia in older patients in Ontario. Multivariable conditional logistic regression analysis is used to study the influence of the said drugs. Findings reveal that approximately 60 % of hyperkalaemia in older patients who take spironolactone and treated with urinary tract infection antibiotics can be avoided without trimethoprim-sulfamethoxazole.