Back to Search
Start Over
Histamine release reaction of basophils in chronic granulocytic leukaemia. Induction by heterologous anti-immunoglobulin E, concanavaline A, and phytohaemagglutinin; effect of heavy water.
- Source :
- Journal of Clinical Pathology; Aug1978, Vol. 31 Issue 8, p749-752, 4p, 2 Charts, 3 Graphs
- Publication Year :
- 1978
-
Abstract
- Basophils possess membrane bound IgE molecules, and immunological activation leads to a secretory process with cell degranulation and histamine release. Heterologous anti IgE, concanavaline A, and phytohaemagglutinin are potent non-cytotoxic releasing agents. They operate by a mechanism similar to that of immunological activation. Heavy water is not a histamine releasing inducer but it increases histamine release of the cells. We studied the histamine release reaction of leukaemic basophils in 10 patients and found a physiological response such as that previously reported with normal human basophils. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 00219746
- Volume :
- 31
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 66092530